Pseudomonas aeruginosa PAO1, PA1636 (kdpD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1636
Name
kdpD
Replicon chromosome
Genomic location 1780536 - 1783193 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_250327.1
GI 15596833
Affymetrix PA1636_kdpD_at
Entrez 883029
GenBank AAG05025.1
INSDC AAG05025.1
NCBI Locus Tag PA1636
protein_id(GenBank) gb|AAG05025.1|AE004591_5|gnl|PseudoCAP|PA1636
TIGR NTL03PA01637
UniParc UPI00000C541C
UniProtKB Acc Q9I389
UniProtKB ID Q9I389_PSEAE
UniRef100 UniRef100_Q9I389
UniRef50 UniRef50_Q48K33
UniRef90 UniRef90_Q9I389

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component sensor KdpD
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -10.76
Kyte-Doolittle Hydrophobicity Value -0.111
Molecular Weight (kDa) 97.0
Isoelectric Point (pI) 6.15

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 620 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003738 (513 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1636
Search term: kdpD

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
The products of the kdpDE operon are required for expression of the Kdp ATPase of Escherichia coli.
Polarek JW, Williams G, Epstein W
J Bacteriol 1992 Apr;174(7):2145-51
PubMed ID: 1532387
KdpD and KdpE, proteins that control expression of the kdpABC operon, are members of the two-component sensor-effector class of regulators.
Walderhaug MO, Polarek JW, Voelkner P, Daniel JM, Hesse JE, Altendorf K, Epstein W
J Bacteriol 1992 Apr;174(7):2152-9
PubMed ID: 1532388
Characterization of the KdpD protein, the sensor kinase of the K(+)-translocating Kdp system of Escherichia coli.
Voelkner P, Puppe W, Altendorf K
Eur J Biochem 1993 Nov 1;217(3):1019-26
PubMed ID: 8223625