Pseudomonas aeruginosa PAO1, PA1663 (sfa2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1663
Name
sfa2
Replicon chromosome
Genomic location 1813395 - 1814906 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250354.1
GI 15596860
Affymetrix PA1663_at
Entrez 880608
GenBank AAG05052.1
INSDC AAG05052.1
NCBI Locus Tag PA1663
protein_id(GenBank) gb|AAG05052.1|AE004594_4|gnl|PseudoCAP|PA1663
TIGR NTL03PA01664
UniParc UPI00000C5435
UniProtKB Acc Q9I362
UniProtKB ID Q9I362_PSEAE
UniRef100 UniRef100_U8N5C2
UniRef50 UniRef50_G8Q740
UniRef90 UniRef90_B7UV58

Product

Feature Type CDS
Coding Frame 1
Product Name
Sfa2
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -6.42
Kyte-Doolittle Hydrophobicity Value -0.049
Molecular Weight (kDa) 55.3
Isoelectric Point (pI) 6.11

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database PseudoCAP
Category Hcp secretion island-2 encoded type VI secretion system (H2-T6SS)
Evidence ECO:0000317
genomic context evidence used in manual assertion
Host Organism Homo sapiens
Notes H2-T6SS rendered inactive via clpV2 deletion.
Reference 22665491

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 458 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003720 (433 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1663
Search term: sfa2
Search term: Sfa2

Human Homologs

References

Initial cloning and sequencing of hydHG, an operon homologous to ntrBC and regulating the labile hydrogenase activity in Escherichia coli K-12.
Stoker K, Reijnders WN, Oltmann LF, Stouthamer AH
J Bacteriol 1989 Aug;171(8):4448-56
PubMed ID: 2666400