Pseudomonas aeruginosa PAO1, PA1681 (aroC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1681
Name
aroC
Replicon chromosome
Genomic location 1830879 - 1831970 (+ strand)
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_250372.1
GI 15596878
Affymetrix PA1681_aroC_at
Entrez 879481
GenBank AAG05070.1
INSDC AAG05070.1
NCBI Locus Tag PA1681
protein_id(GenBank) gb|AAG05070.1|AE004595_9|gnl|PseudoCAP|PA1681
TIGR NTL03PA01682
UniParc UPI0000125FA9
UniProtKB Acc Q9I344
UniProtKB ID AROC_PSEAE
UniRef100 UniRef100_B7UV40
UniRef50 UniRef50_A8EV89
UniRef90 UniRef90_A4XTH9

Product

Feature Type CDS
Coding Frame 1
Product Name
chorismate synthase
Product Name Confidence: Class 2
Synonyms 5-enolpyruvylshikimate-3-phosphate phospholyase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.89
Kyte-Doolittle Hydrophobicity Value -0.306
Molecular Weight (kDa) 39.0
Isoelectric Point (pI) 6.61

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5Z9A LYASE 02/02/18 Crystal structure of chorismate synthase from Pseudomonas aeruginosa Pseudomonas aeruginosa (strain LESB58) 2.79 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 619 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003709 (532 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1681
Search term: aroC

Human Homologs

References

The overexpression, purification and complete amino acid sequence of chorismate synthase from Escherichia coli K12 and its comparison with the enzyme from Neurospora crassa.
White PJ, Millar G, Coggins JR
Biochem J 1988 Apr 15;251(2):313-22
PubMed ID: 2969724