Pseudomonas aeruginosa PAO1, PA1713 (exsA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1713
Name
exsA
Replicon chromosome
Genomic location 1857273 - 1858109 (+ strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250404.1
GI 15596910
Affymetrix PA1713_exsA_at
DNASU PaCD00006775
Entrez 879712
GenBank AAG05102.1
INSDC AAG05102.1
NCBI Locus Tag PA1713
protein_id(GenBank) gb|AAG05102.1|AE004598_1|gnl|PseudoCAP|PA1713
TIGR NTL03PA01714
UniParc UPI000012A39A
UniProtKB Acc P26993
UniProtKB ID EXSA_PSEAE
UniRef100 UniRef100_P26993
UniRef50 UniRef50_P26993
UniRef90 UniRef90_P26993

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator ExsA
Product Name Confidence: Class 1
Synonyms S synthesis trans-regulatory protein ExsA
Evidence for Translation
Charge (pH 7) 5.23
Kyte-Doolittle Hydrophobicity Value -0.105
Molecular Weight (kDa) 31.6
Isoelectric Point (pI) 8.47

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 1
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4ZUA TRANSCRIPTION 05/15/15 Crystal structure of the ExsA regulatory domain Pseudomonas aeruginosa PAO1 2.5 X-RAY DIFFRACTION 100.0

Virulence Evidence

Source 1
Database VFDB : VF0083
Category T3SS
Evidence
Host Organism
Notes
Reference 11372029

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 379 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003676 (315 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1713
Search term: exsA

Human Homologs

References

Analyses of the DNA-binding and transcriptional activation properties of ExsA, the transcriptional activator of the Pseudomonas aeruginosa exoenzyme S regulon.
Hovey AK, Frank DW
J Bacteriol 1995 Aug;177(15):4427-36
PubMed ID: 7635828
Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa.
Frank DW, Iglewski BH
J Bacteriol 1991 Oct;173(20):6460-8
PubMed ID: 1655713