Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA1806
|
Name |
fabI
Synonym: envM |
Replicon | chromosome |
Genomic location | 1961227 - 1962024 (- strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
RefSeq | NP_250497.1 |
GI | 15597003 |
Affymetrix | PA1806_fabI_at |
Entrez | 878311 |
GenBank | AAG05195.1 |
INSDC | AAG05195.1 |
NCBI Locus Tag | PA1806 |
protein_id(GenBank) | gb|AAG05195.1|AE004607_1|gnl|PseudoCAP|PA1806 |
TIGR | NTL03PA01807 |
UniParc | UPI000012A481 |
UniProtKB Acc | Q9ZFE4 |
UniProtKB ID | FABI_PSEAE |
UniRef100 | UniRef100_Q9ZFE4 |
UniRef50 | UniRef50_Q9ZFE4 |
UniRef90 | UniRef90_Q9ZFE4 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
NADH-dependent enoyl-ACP reductase
|
Synonyms | |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -3.13 |
Kyte-Doolittle Hydrophobicity Value | 0.028 |
Molecular Weight (kDa) | 28.0 |
Isoelectric Point (pI) | 5.72 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
4NQZ | OXIDOREDUCTASE | 11/26/13 | Crystal Structure of the Pseudomonas aeruginosa Enoyl-Acyl Carrier Protein Reductase (FabI) in apo form | Pseudomonas aeruginosa | 2.604 | X-RAY DIFFRACTION | 100.0 |
4NR0 | OXIDOREDUCTASE | 11/26/13 | Crystal structure of the Pseudomonas aeruginosa Enoyl-Acyl Carrier Protein Reductase (FabI) in complex with NAD+ and triclosan | Pseudomonas aeruginosa | 1.799 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 625 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG003591 (441 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA1806
Search term: fabI
Search term: NADH-dependent enoyl-ACP reductase
|
Protein EnvM is the NADH-dependent enoyl-ACP reductase (FabI) of Escherichia coli.
Bergler H, Wallner P, Ebeling A, Leitinger B, Fuchsbichler S, Aschauer H, Kollenz G, Högenauer G, Turnowsky F
J Biol Chem 1994 Feb 25;269(8):5493-6
PubMed ID: 8119879
|
Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (FabI): a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis.
Hoang TT, Schweizer HP
J Bacteriol 1999 Sep;181(17):5489-97
PubMed ID: 10464225
|