Pseudomonas aeruginosa PAO1, PA1861 (modC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1861
Name
modC
Replicon chromosome
Genomic location 2020625 - 2021710 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250552.1
GI 15597058
Affymetrix PA1861_modC_at
Entrez 882019
GenBank AAG05250.1
INSDC AAG05250.1
NCBI Locus Tag PA1861
protein_id(GenBank) gb|AAG05250.1|AE004612_4|gnl|PseudoCAP|PA1861
TIGR NTL03PA01862
UniParc UPI00000C54D9
UniProtKB Acc Q9I2N4
UniProtKB ID MODC_PSEAE
UniRef100 UniRef100_Q9I2N4
UniRef50 UniRef50_Q9I2N4
UniRef90 UniRef90_Q9I2N4

Product

Feature Type CDS
Coding Frame 1
Product Name
molybdenum transport protein ModC
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 4.33
Kyte-Doolittle Hydrophobicity Value -0.055
Molecular Weight (kDa) 39.8
Isoelectric Point (pI) 8.49

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003542 (528 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1861
Search term: modC

Human Homologs

Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily A member 5 [Source:HGNC Symbol;Acc:HGNC:35]
E-value: 6.7e-14
Percent Identity: 28.6
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily A member 5 [Source:HGNC Symbol;Acc:HGNC:35]
E-value: 6.7e-14
Percent Identity: 28.6
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily A member 5 [Source:HGNC Symbol;Acc:HGNC:35]
E-value: 6.7e-14
Percent Identity: 28.6
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily A member 5 [Source:HGNC Symbol;Acc:HGNC:35]
E-value: 6.7e-14
Percent Identity: 28.6

References

Characterization of genes involved in molybdenum transport in Azotobacter vinelandii.
Luque F, Mitchenall LA, Chapman M, Christine R, Pau RN
Mol Microbiol 1993 Feb;7(3):447-59
PubMed ID: 8384683
Molecular analysis of the molybdate uptake operon, modABCD, of Escherichia coli and modR, a regulatory gene.
Walkenhorst HM, Hemschemeier SK, Eichenlaub R
Microbiol Res 1995 Nov;150(4):347-61
PubMed ID: 8564363