Pseudomonas aeruginosa PAO1, PA1984 (exaC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1984
Name
exaC
Synonym: exaC1
Replicon chromosome
Genomic location 2169988 - 2171508 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_250674.1
GI 15597180
Affymetrix PA1984_s_at
Entrez 880413
GenBank AAG05372.1
INSDC AAG05372.1
NCBI Locus Tag PA1984
protein_id(GenBank) gb|AAG05372.1|AE004625_2|gnl|PseudoCAP|PA1984
TIGR NTL03PA01984
UniParc UPI00000C5541
UniProtKB Acc Q9I2C4
UniProtKB ID Q9I2C4_PSEAE
UniRef100 UniRef100_Q9I2C4
UniRef50 UniRef50_P37685
UniRef90 UniRef90_A0A024HMC9

Product

Feature Type CDS
Coding Frame 1
Product Name
NAD+ dependent aldehyde dehydrogenase ExaC
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -9.79
Kyte-Doolittle Hydrophobicity Value -0.055
Molecular Weight (kDa) 54.9
Isoelectric Point (pI) 5.35

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 595 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001661 (779 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1984
Search term: exaC

Human Homologs

Ensembl 110, assembly GRCh38.p14
aldehyde dehydrogenase 2 family member [Source:HGNC Symbol;Acc:HGNC:404]
E-value: 3.0e-97
Percent Identity: 41.3

References

Identification and molecular characterization of the gene coding for acetaldehyde dehydrogenase II (acoD) of Alcaligenes eutrophus.
Priefert H, Krüger N, Jendrossek D, Schmidt B, Steinbüchel A
J Bacteriol 1992 Feb;174(3):899-907
PubMed ID: 1732222
Cytochrome c550 is an essential component of the quinoprotein ethanol oxidation system in Pseudomonas aeruginosa: cloning and sequencing of the genes encoding cytochrome c550 and an adjacent acetaldehyde dehydrogenase.
Schobert M, Görisch H
Microbiology (Reading) 1999 Feb;145 ( Pt 2):471-481
PubMed ID: 10075429
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994