Pseudomonas aeruginosa PAO1, PA2005 (hbcR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2005
Name
hbcR
Synonym: (R)-3-hydroxybutyrate catabolism regulator
Replicon chromosome
Genomic location 2192544 - 2193989 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentTranscriptional regulator of the PA2004-bdhA operon

Cross-References

RefSeq NP_250695.1
GI 15597201
Affymetrix PA2005_at
Entrez 879178
GenBank AAG05393.1
INSDC AAG05393.1
NCBI Locus Tag PA2005
protein_id(GenBank) gb|AAG05393.1|AE004627_1|gnl|PseudoCAP|PA2005
TIGR NTL03PA02005
UniParc UPI00000C5554
UniProtKB Acc Q9I2A4
UniProtKB ID Q9I2A4_PSEAE
UniRef100 UniRef100_Q9I2A4
UniRef50 UniRef50_G8Q7L2
UniRef90 UniRef90_Q9I2A4

Product

Feature Type CDS
Coding Frame 1
Product Name
HbcR
Product Name Confidence: Class 1
Synonyms probable transcriptional regulator
Evidence for Translation
Charge (pH 7) -1.11
Kyte-Doolittle Hydrophobicity Value -0.110
Molecular Weight (kDa) 52.4
Isoelectric Point (pI) 6.74

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 458 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003271 (473 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2005
Search term: hbcR
Search term: HbcR

Human Homologs

References

The metabolism of (R)-3-hydroxybutyrate is regulated by the enhancer-binding protein PA2005 and the alternative sigma factor RpoN in Pseudomonas aeruginosa PAO1.
Lundgren BR, Harris JR, Sarwar Z, Scheel RA, Nomura CT
Microbiology (Reading) 2015 Nov;161(Pt 11):2232-42
PubMed ID: 26311173