Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA2009
|
Name |
hmgA
|
Replicon | chromosome |
Genomic location | 2197432 - 2198730 (- strand) |
Transposon Mutants | 1 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
RefSeq | NP_250699.1 |
GI | 15597205 |
Affymetrix | PA2009_hmgA_at |
Entrez | 877745 |
GenBank | AAG05397.1 |
INSDC | AAD23385.1 |
NCBI Locus Tag | PA2009 |
protein_id(GenBank) | gb|AAG05397.1|AE004627_5|gnl|PseudoCAP|PA2009 |
TIGR | NTL03PA02009 |
UniParc | UPI000012C6CC |
UniProtKB Acc | Q9X4G0 |
UniProtKB ID | HGD_PSEAE |
UniRef100 | UniRef100_B7VA96 |
UniRef50 | UniRef50_Q88E47 |
UniRef90 | UniRef90_B7VA96 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
homogentisate 1,2-dioxygenase
|
Synonyms |
homogentisicase |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
|
Charge (pH 7) | -6.01 |
Kyte-Doolittle Hydrophobicity Value | -0.267 |
Molecular Weight (kDa) | 47.8 |
Isoelectric Point (pI) | 5.85 |
Individual Mappings | |
Additional evidence for subcellular localization |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 122 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG003430 (505 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA2009
Search term: hmgA
Search term: homogentisate 1,2-dioxygenase
|
Ensembl
110, assembly
GRCh38.p14
|
homogentisate 1,2-dioxygenase [Source:HGNC Symbol;Acc:HGNC:4892]
E-value:
5.0e-125
Percent Identity:
52.9
|
Molecular characterization of a gene encoding a homogentisate dioxygenase from Aspergillus nidulans and identification of its human and plant homologues.
Fernández-Cañón JM, Peñalva MA
J Biol Chem 1995 Sep 8;270(36):21199-205
PubMed ID: 7673153
|
The molecular basis of alkaptonuria.
Fernández-Cañón JM, Granadino B, Beltrán-Valero de Bernabé D, Renedo M, Fernández-Ruiz E, Peñalva MA, Rodríguez de Córdoba S
Nat Genet 1996 Sep;14(1):19-24
PubMed ID: 8782815
|
The human homogentisate 1,2-dioxygenase (HGO) gene.
Granadino B, Beltrán-Valero de Bernabé D, Fernández-Cañón JM, Peñalva MA, Rodríguez de Córdoba S
Genomics 1997 Jul 15;43(2):115-22
PubMed ID: 9244427
|
A gene cluster encoding steps in conversion of naphthalene to gentisate in Pseudomonas sp. strain U2.
Fuenmayor SL, Wild M, Boyes AL, Williams PA
J Bacteriol 1998 May;180(9):2522-30
PubMed ID: 9573207
|
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
|