Pseudomonas aeruginosa PAO1, PA2025 (gor)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2025
Name
gor
Replicon chromosome
Genomic location 2216688 - 2218043 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250715.1
GI 15597221
Affymetrix PA2025_gor_at
Entrez 878570
GenBank AAG05413.1
INSDC AAG05413.1
NCBI Locus Tag PA2025
protein_id(GenBank) gb|AAG05413.1|AE004629_2|gnl|PseudoCAP|PA2025
TIGR NTL03PA02025
UniParc UPI000012BC04
UniProtKB Acc P23189
UniProtKB ID GSHR_PSEAE
UniRef100 UniRef100_P23189
UniRef50 UniRef50_P23189
UniRef90 UniRef90_P23189

Product

Feature Type CDS
Coding Frame 1
Product Name
glutathione reductase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.45
Kyte-Doolittle Hydrophobicity Value -0.051
Molecular Weight (kDa) 49.2
Isoelectric Point (pI) 6.30

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 651 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003417 (481 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2025
Search term: gor

Human Homologs

Ensembl 110, assembly GRCh38.p14
glutathione-disulfide reductase [Source:HGNC Symbol;Acc:HGNC:4623]
E-value: 1.6e-97
Percent Identity: 43.8

References

Molecular characterization of the gor gene encoding glutathione reductase from Pseudomonas aeruginosa: determinants of substrate specificity among pyridine nucleotide-disulphide oxidoreductases.
Perry AC, Ni Bhriain N, Brown NL, Rouch DA
Mol Microbiol 1991 Jan;5(1):163-71
PubMed ID: 1849605