Pseudomonas aeruginosa PAO1, PA2193 (hcnA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2193
Name
hcnA
Replicon chromosome
Genomic location 2412546 - 2412860 (+ strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250883.1
GI 15597389
Affymetrix PA2193_hcnA_at
DNASU PaCD00006974
Entrez 882197
GenBank AAG05581.1
INSDC AAG05581.1
NCBI Locus Tag PA2193
protein_id(GenBank) gb|AAG05581.1|AE004646_2|gnl|PseudoCAP|PA2193
TIGR NTL03PA02193
UniParc UPI00000D4272
UniProtKB Acc G3XD67
UniProtKB ID HCNA_PSEAE
UniRef100 UniRef100_G3XD67
UniRef50 UniRef50_G3XD67
UniRef90 UniRef90_G3XD67

Product

Feature Type CDS
Coding Frame 1
Product Name
hydrogen cyanide synthase HcnA
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 3.04
Kyte-Doolittle Hydrophobicity Value -0.353
Molecular Weight (kDa) 11.4
Isoelectric Point (pI) 8.24

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB
Category Hydrogen cyanide production
Evidence
Host Organism
Notes
Reference

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 95 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003288 (375 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2193
Search term: hcnA

Human Homologs

References

Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0.
Laville J, Blumer C, Von Schroetter C, Gaia V, Défago G, Keel C, Haas D
J Bacteriol 1998 Jun;180(12):3187-96
PubMed ID: 9620970