Pseudomonas aeruginosa PAO1, PA2258 (ptxR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2258
Name
ptxR
Replicon chromosome
Genomic location 2486355 - 2487293 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_250948.1
GI 15597454
Affymetrix PA2258_ptxR_at
Entrez 878030
GenBank AAG05646.1
INSDC AAG05646.1
NCBI Locus Tag PA2258
protein_id(GenBank) gb|AAG05646.1|AE004651_8|gnl|PseudoCAP|PA2258
TIGR NTL03PA02258
UniParc UPI00001329E5
UniProtKB Acc P72131
UniProtKB ID PTXR_PSEAE
UniRef100 UniRef100_P72131
UniRef50 UniRef50_P72131
UniRef90 UniRef90_P72131

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator PtxR
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 8.86
Kyte-Doolittle Hydrophobicity Value -0.095
Molecular Weight (kDa) 35.0
Isoelectric Point (pI) 10.15

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 515 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001255 (664 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2258
Search term: ptxR

Human Homologs

References

Isolation and characterization of a Pseudomonas aeruginosa gene, ptxR, which positively regulates exotoxin A production.
Hamood AN, Colmer JA, Ochsner UA, Vasil ML
Mol Microbiol 1996 Jul;21(1):97-110
PubMed ID: 8843437