Pseudomonas aeruginosa PAO1, PA2259 (ptxS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2259
Name
ptxS
Replicon chromosome
Genomic location 2487856 - 2488878 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250949.1
GI 15597455
Affymetrix PA2259_ptxS_at
Entrez 877811
GenBank AAG05647.1
INSDC AAG05647.1
NCBI Locus Tag PA2259
protein_id(GenBank) gb|AAG05647.1|AE004651_9|gnl|PseudoCAP|PA2259
TIGR NTL03PA02259
UniParc UPI00000D429A
UniProtKB Acc G3XD97
UniProtKB ID G3XD97_PSEAE
UniRef100 UniRef100_W0YTS1
UniRef50 UniRef50_Q4KD55
UniRef90 UniRef90_A6V5K6

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator PtxS
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.74
Kyte-Doolittle Hydrophobicity Value -0.230
Molecular Weight (kDa) 37.4
Isoelectric Point (pI) 6.85

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 373 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003231 (452 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2259
Search term: ptxS

Human Homologs

References

Characterization of ptxS, a Pseudomonas aeruginosa gene which interferes with the effect of the exotoxin A positive regulatory gene, ptxR.
Colmer JA, Hamood AN
Mol Gen Genet 1998 May;258(3):250-9
PubMed ID: 9645431