Pseudomonas aeruginosa PAO1, PA2359

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2359
Name
Synonym: sfnR2
Replicon chromosome
Genomic location 2605937 - 2607022 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_251049.1
GI 15597555
Affymetrix PA2359_at
DNASU PaCD00007033
Entrez 882226
GenBank AAG05747.1
INSDC AAG05747.1
NCBI Locus Tag PA2359
protein_id(GenBank) gb|AAG05747.1|AE004662_2|gnl|PseudoCAP|PA2359
TIGR NTL03PA02359
UniParc UPI00000C568B
UniProtKB Acc Q9I1C0
UniProtKB ID Q9I1C0_PSEAE
UniRef100 UniRef100_U8NG09
UniRef50 UniRef50_A1K7Z0
UniRef90 UniRef90_U8NG09

Product

Feature Type CDS
Coding Frame 1
Product Name
probable transcriptional regulator
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 2.50
Kyte-Doolittle Hydrophobicity Value -0.173
Molecular Weight (kDa) 40.1
Isoelectric Point (pI) 7.48

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database PseudoCAP
Category Hcp secretion island-3 encoded type VI secretion system (H3-T6SS)
Evidence ECO:0000317
genomic context evidence used in manual assertion
Host Organism Caenorhabditis elegans
Notes
Infection model Caenorhabditis elegans slow killing assay. H3-T6SS rendered inactive via clpV3 deletion.
Reference 24204589

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 452 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003160 (766 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2359

Human Homologs

References

FlbD of Caulobacter crescentus is a homologue of the NtrC (NRI) protein and activates sigma 54-dependent flagellar gene promoters.
Ramakrishnan G, Newton A
Proc Natl Acad Sci U S A 1990 Mar;87(6):2369-73
PubMed ID: 2315326
A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.
Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordoñez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ
Science 2006 Jun 9;312(5779):1526-30
PubMed ID: 16763151
Divergent control of two type VI secretion systems by RpoN in Pseudomonas aeruginosa.
Sana TG, Soscia C, Tonglet CM, Garvis S, Bleves S
PLoS One 2013;8(10):e76030
PubMed ID: 24204589
SfnR2 Regulates Dimethyl Sulfide-Related Utilization in Pseudomonas aeruginosa PAO1.
Lundgren BR, Sarwar Z, Feldman KS, Shoytush JM, Nomura CT
J Bacteriol 2019 Feb 15;201(4)
PubMed ID: 30478084