Pseudomonas aeruginosa PAO1, PA2443 (sdaA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2443
Name
sdaA
Replicon chromosome
Genomic location 2740977 - 2742353 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs

Cross-References

RefSeq NP_251133.1
GI 15597639
Affymetrix PA2443_sdaA_at
Entrez 882930
GenBank AAG05831.1
INSDC AAG05831.1
NCBI Locus Tag PA2443
protein_id(GenBank) gb|AAG05831.1|AE004671_7|gnl|PseudoCAP|PA2443
TIGR NTL03PA02443
UniParc UPI00000C56D7
UniProtKB Acc Q9I139
UniProtKB ID Q9I139_PSEAE
UniRef100 UniRef100_Q9I139
UniRef50 UniRef50_O86564
UniRef90 UniRef90_A6V533

Product

Feature Type CDS
Coding Frame 1
Product Name
L-serine dehydratase
Product Name Confidence: Class 2
Synonyms L-serine deaminase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.12
Kyte-Doolittle Hydrophobicity Value -0.010
Molecular Weight (kDa) 48.9
Isoelectric Point (pI) 6.78

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 360 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003095 (985 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2443
Search term: sdaA

Human Homologs

References

L-serine degradation in Escherichia coli K-12: cloning and sequencing of the sdaA gene.
Su HS, Lang BF, Newman EB
J Bacteriol 1989 Sep;171(9):5095-102
PubMed ID: 2504697
Sequencing and characterization of the sdaB gene from Escherichia coli K-12.
Shao Z, Newman EB
Eur J Biochem 1993 Mar 15;212(3):777-84
PubMed ID: 8385012