Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA2570
|
Name |
lecA
Synonym: lecA (changed from pa1L) Synonym: pa1L |
Replicon | chromosome |
Genomic location | 2905182 - 2905550 (- strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
RefSeq | NP_251260.1 |
GI | 15597766 |
Affymetrix | PA2570_pa1L_at |
DNASU | PaCD00007110 |
Entrez | 882335 |
GenBank | AAG05958.1 |
INSDC | AAG05958.1 |
NCBI Locus Tag | PA2570 |
protein_id(GenBank) | gb|AAG05958.1|AE004685_4|gnl|PseudoCAP|PA2570 |
TIGR | NTL03PA02570 |
UniParc | UPI0000165EC5 |
UniProtKB Acc | Q05097 |
UniProtKB ID | PA1L_PSEAE |
UniRef100 | UniRef100_Q05097 |
UniRef50 | UniRef50_Q05097 |
UniRef90 | UniRef90_Q05097 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
LecA
|
Synonyms |
PA-I galactophilic lectin LecA (changed from PA-I galactophilic lectin) |
Evidence for Translation | |
Charge (pH 7) | -2.60 |
Kyte-Doolittle Hydrophobicity Value | -0.148 |
Molecular Weight (kDa) | 12.9 |
Isoelectric Point (pI) | 4.88 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
4YW7 | SUGAR BINDING PROTEIN | 03/20/15 | Structural Insight into Divalent Galactoside Binding to Pseudomonas aeruginosa lectin LecA | Pseudomonas aeruginosa | 1.82 | X-RAY DIFFRACTION | 100.0 |
3ZYB | SUGAR BINDING PROTEIN | 08/19/11 | CRYSTAL STRUCTURE OF PA-IL LECTIN COMPLEXED WITH GALAG0 AT 2.3 A RESOLUTION | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1); SYNTHETIC CONSTRUCT | 2.29 | X-RAY DIFFRACTION | 100.0 |
3ZYH | SUGAR BINDING PROTEIN/INHIBITOR | 08/23/11 | CRYSTAL STRUCTURE OF PA-IL LECTIN COMPLEXED WITH GALBG0 AT 1.5 A RESOLUTION | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 1.501 | X-RAY DIFFRACTION | 100.0 |
4LJH | SUGAR BINDING PROTEIN | 07/04/13 | Crystal Structure of Pseudomonas aeruginosa Lectin LecA Complexed with 1-Methyl-3-indolyl-b-D-galactopyranoside at 1.45 A Resolution | Pseudomonas aeruginosa | 1.45 | X-RAY DIFFRACTION | 100.0 |
3ZYF | SUGAR BINDING PROTEIN | 08/22/11 | CRYSTAL STRUCTURE OF PA-IL LECTIN COMPLEXED WITH NPG AT 1.9 A RESOLUTION | PSEUDOMONAS AERUGINOSA | 1.944 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 4 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG003000 (296 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA2570
Search term: lecA
Search term: LecA
|
The galactophilic lectin, LecA, contributes to biofilm development in Pseudomonas aeruginosa.
Diggle SP, Stacey RE, Dodd C, Cámara M, Williams P, Winzer K
Environ Microbiol 2006 Jun;8(6):1095-104
PubMed ID: 16689730
|
On the specificity of the D-galactose-binding lectin (PA-I) of Pseudomonas aeruginosa and its strong binding to hydrophobic derivatives of D-galactose and thiogalactose.
Garber N, Guempel U, Belz A, Gilboa-Garber N, Doyle RJ
Biochim Biophys Acta 1992 Jun 12;1116(3):331-3
PubMed ID: 1610890
|
Analysis of the amino acid sequence of the Pseudomonas aeruginosa galactophilic PA-I lectin.
Avichezer D, Katcoff DJ, Garber NC, Gilboa-Garber N
J Biol Chem 1992 Nov 15;267(32):23023-7
PubMed ID: 1429650
|
Pseudomonas aeruginosa PA-I lectin gene molecular analysis and expression in Escherichia coli.
Avichezer D, Gilboa-Garber N, Garber NC, Katcoff DJ
Biochim Biophys Acta 1994 May 17;1218(1):11-20
PubMed ID: 8193158
|
PA-I and PA-II lectin interactions with the ABO(H) and P blood group glycosphingolipid antigens may contribute to the broad spectrum adherence of Pseudomonas aeruginosa to human tissues in secondary infections.
Gilboa-Garber N, Sudakevitz D, Sheffi M, Sela R, Levene C
Glycoconj J 1994 Oct;11(5):414-7
PubMed ID: 7696845
|