Pseudomonas aeruginosa PAO1, PA2587 (pqsH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2587
Name
pqsH
Replicon chromosome
Genomic location 2926773 - 2927921 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs
CommentQuinolone signal response
Commenttranscription of pqsH regulated by the LasI/R quorum-sensing system

Cross-References

RefSeq NP_251277.1
GI 15597783
Affymetrix PA2587_at
Entrez 879540
GenBank AAG05975.1
INSDC AAG05975.1
NCBI Locus Tag PA2587
protein_id(GenBank) gb|AAG05975.1|AE004687_4|gnl|PseudoCAP|PA2587
TIGR NTL03PA02587
UniParc UPI00000C5753
UniProtKB Acc Q9I0Q0
UniProtKB ID PQSH_PSEAE
UniRef100 UniRef100_Q9I0Q0
UniRef50 UniRef50_Q02N79
UniRef90 UniRef90_Q02N79

Product

Feature Type CDS
Coding Frame 1
Product Name
probable FAD-dependent monooxygenase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 0.78
Kyte-Doolittle Hydrophobicity Value -0.010
Molecular Weight (kDa) 42.1
Isoelectric Point (pI) 7.15

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 224 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001490 (1026 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2587
Search term: pqsH

Human Homologs

References

Functions required for extracellular quinolone signaling by Pseudomonas aeruginosa.
Gallagher LA, McKnight SL, Kuznetsova MS, Pesci EC, Manoil C
J Bacteriol 2002 Dec;184(23):6472-80
PubMed ID: 12426334