Pseudomonas aeruginosa PAO1, PA2615 (ftsK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2615
Name
ftsK
Replicon chromosome
Genomic location 2956805 - 2959240 (- strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251305.1
GI 15597811
Affymetrix PA2615_ftsK_at
Entrez 882321
GenBank AAG06003.1
INSDC AAG06003.1
NCBI Locus Tag PA2615
protein_id(GenBank) gb|AAG06003.1|AE004690_3|gnl|PseudoCAP|PA2615
TIGR NTL03PA02615
UniParc UPI00000C576B
UniProtKB Acc Q9I0M3
UniProtKB ID FTSK_PSEAE
UniRef100 UniRef100_Q9I0M3
UniRef50 UniRef50_Q9I0M3
UniRef90 UniRef90_Q9I0M3

Product

Feature Type CDS
Coding Frame 1
Product Name
cell division protein FtsK
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.15
Kyte-Doolittle Hydrophobicity Value -0.049
Molecular Weight (kDa) 88.9
Isoelectric Point (pI) 6.85

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2IUU MEMBRANE PROTEIN 06/07/06 P. aeruginosa FtsK motor domain, hexamer PSEUDOMONAS AERUGINOSA 2.9 X-RAY DIFFRACTION 100.0
6T8B DNA BINDING PROTEIN 10/24/19 FtsK motor domain with dsDNA, translocating state Pseudomonas aeruginosa PAO1; SYNTHETIC CONSTRUCT 3.65 ELECTRON MICROSCOPY 100.0
2IUT MEMBRANE PROTEIN 06/07/06 P. aeruginosa FtsK motor domain, dimeric PSEUDOMONAS AERUGINOSA 2.25 X-RAY DIFFRACTION 100.0
6T8O DNA BINDING PROTEIN 10/24/19 Stalled FtsK motor domain bound to dsDNA end Pseudomonas aeruginosa PAO1; SYNTHETIC CONSTRUCT 3.99 ELECTRON MICROSCOPY 100.0
6T8G DNA BINDING PROTEIN 10/24/19 Stalled FtsK motor domain bound to dsDNA Pseudomonas aeruginosa PAO1; SYNTHETIC CONSTRUCT 4.34 ELECTRON MICROSCOPY 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 540 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002936 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2615
Search term: ftsK

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
A new Escherichia coli cell division gene, ftsK.
Begg KJ, Dewar SJ, Donachie WD
J Bacteriol 1995 Nov;177(21):6211-22
PubMed ID: 7592387
Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to beta-lactam antibiotics.
Alvarez-Ortega C, Wiegand I, Olivares J, Hancock RE, Martínez JL
Antimicrob Agents Chemother 2010 Oct;54(10):4159-67
PubMed ID: 20679510