Pseudomonas aeruginosa PAO1, PA2687 (pfeS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2687
Name
pfeS
Replicon chromosome
Genomic location 3038803 - 3040143 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251377.1
GI 15597883
Affymetrix PA2687_pfeS_at
Entrez 882765
GenBank AAG06075.1
INSDC AAG06075.1
NCBI Locus Tag PA2687
protein_id(GenBank) gb|AAG06075.1|AE004696_9|gnl|PseudoCAP|PA2687
TIGR NTL03PA02687
UniParc UPI000013174D
UniProtKB Acc Q04804
UniProtKB ID PFES_PSEAE
UniRef100 UniRef100_Q04804
UniRef50 UniRef50_Q04804
UniRef90 UniRef90_Q04804

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component sensor PfeS
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -10.51
Kyte-Doolittle Hydrophobicity Value -0.254
Molecular Weight (kDa) 50.5
Isoelectric Point (pI) 5.74

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 1
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3KYZ TRANSFERASE 12/07/09 The crystal structure of the sensor domain of two-component sensor PfeS from Pseudomonas aeruginosa PA01 Pseudomonas aeruginosa 1.497 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 612 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002874 (368 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2687
Search term: pfeS

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295