Pseudomonas aeruginosa PAO1, PA2923 (hisJ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2923
Name
hisJ
Replicon chromosome
Genomic location 3278638 - 3279423 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251613.1
GI 15598119
Affymetrix PA2923_hisJ_at
Entrez 882695
GenBank AAG06311.1
INSDC AAG06311.1
NCBI Locus Tag PA2923
protein_id(GenBank) gb|AAG06311.1|AE004718_8|gnl|PseudoCAP|PA2923
TIGR NTL03PA02923
UniParc UPI00000C5886
UniProtKB Acc Q9HZS4
UniProtKB ID Q9HZS4_PSEAE
UniRef100 UniRef100_W0YU80
UniRef50 UniRef50_D4I7H0
UniRef90 UniRef90_Q02P85

Product

Feature Type CDS
Coding Frame 1
Product Name
periplasmic histidine-binding protein HisJ
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 1.18
Kyte-Doolittle Hydrophobicity Value -0.145
Molecular Weight (kDa) 28.2
Isoelectric Point (pI) 8.15

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 427 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002654 (348 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2923
Search term: hisJ

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Refined 1.89-A structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport/chemosensory proteins.
Yao N, Trakhanov S, Quiocho FA
Biochemistry 1994 Apr 26;33(16):4769-79
PubMed ID: 8161536