Pseudomonas aeruginosa PAO1, PA2925 (hisM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2925
Name
hisM
Replicon chromosome
Genomic location 3280165 - 3280878 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251615.1
GI 15598121
Affymetrix PA2925_hisM_at
DNASU PaCD00007275
Entrez 882577
GenBank AAG06313.1
INSDC AAG06313.1
NCBI Locus Tag PA2925
protein_id(GenBank) gb|AAG06313.1|AE004718_10|gnl|PseudoCAP|PA2925
TIGR NTL03PA02925
UniParc UPI00000C5888
UniProtKB Acc Q9HZS2
UniProtKB ID Q9HZS2_PSEAE
UniRef100 UniRef100_W0YVX9
UniRef50 UniRef50_P0AEU5
UniRef90 UniRef90_W0YVX9

Product

Feature Type CDS
Coding Frame 1
Product Name
histidine transport system permease HisM
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 5.60
Kyte-Doolittle Hydrophobicity Value 0.560
Molecular Weight (kDa) 26.7
Isoelectric Point (pI) 9.20

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 442 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002652 (435 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2925
Search term: hisM

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Sequence of the complete P protein gene and part of the M protein gene from the histidine transport operon of Escherichia coli compared to that of Salmonella typhimurium.
Kraft R, Leinwand LA
Nucleic Acids Res 1987 Oct 26;15(20):8568
PubMed ID: 3313284