Pseudomonas aeruginosa PAO1, PA2964 (pabC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2964
Name
pabC
Replicon chromosome
Genomic location 3322759 - 3323574 (- strand)
Transposon Mutants 3 transposon mutants in PAO1

Cross-References

RefSeq NP_251654.1
GI 15598160
Affymetrix PA2964_pabC_at
Entrez 880488
GenBank AAG06352.1
INSDC AAG06352.1
NCBI Locus Tag PA2964
protein_id(GenBank) gb|AAG06352.1|AE004722_8|gnl|PseudoCAP|PA2964
TIGR NTL03PA02964
UniParc UPI00000C58AB
UniProtKB Acc Q9HZN6
UniProtKB ID Q9HZN6_PSEAE
UniRef100 UniRef100_Q9HZN6
UniRef50 UniRef50_Q9HZN6
UniRef90 UniRef90_Q9HZN6

Product

Feature Type CDS
Coding Frame 1
Product Name
4-amino-4-deoxychorismate lyase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -4.70
Kyte-Doolittle Hydrophobicity Value -0.044
Molecular Weight (kDa) 29.9
Isoelectric Point (pI) 5.70

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2Y4R LYASE 01/10/11 CRYSTAL STRUCTURE OF 4-AMINO-4-DEOXYCHORISMATE LYASE FROM PSEUDOMONAS AERUGINOSA PSEUDOMONAS AERUGINOSA 1.75 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 499 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002618 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2964
Search term: pabC

Human Homologs

References

p-Aminobenzoate biosynthesis in Escherichia coli. Purification of aminodeoxychorismate lyase and cloning of pabC.
Green JM, Nichols BP
J Biol Chem 1991 Jul 15;266(20):12971-5
PubMed ID: 2071583