Pseudomonas aeruginosa PAO1, PA2979 (kdsB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2979
Name
kdsB
Replicon chromosome
Genomic location 3337692 - 3338456 (- strand)

Cross-References

RefSeq NP_251669.1
GI 15598175
Affymetrix PA2979_kdsB_at
Entrez 880169
GenBank AAG06367.1
INSDC AAG06367.1
NCBI Locus Tag PA2979
protein_id(GenBank) gb|AAG06367.1|AE004723_11|gnl|PseudoCAP|PA2979
TIGR NTL03PA02979
UniParc UPI000012DD72
UniProtKB Acc Q9HZM5
UniProtKB ID KDSB_PSEAE
UniRef100 UniRef100_Q9HZM5
UniRef50 UniRef50_P44490
UniRef90 UniRef90_Q9HZM5

Product

Feature Type CDS
Coding Frame 1
Product Name
3-deoxy-manno-octulosonate cytidylyltransferase
Product Name Confidence: Class 2
Synonyms CMP-KDO synthetase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.61
Kyte-Doolittle Hydrophobicity Value -0.036
Molecular Weight (kDa) 27.6
Isoelectric Point (pI) 5.35

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4XWI TRANSFERASE 01/28/15 X-ray Crystal structure of CMP-KDO Synthase from Pseudomonas aeruginosa Pseudomonas aeruginosa 1.92 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 374 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002603 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2979
Search term: kdsB

Human Homologs

References

Primary structure of CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) from Escherichia coli.
Goldman RC, Bolling TJ, Kohlbrenner WE, Kim Y, Fox JL
J Biol Chem 1986 Dec 5;261(34):15831-5
PubMed ID: 3023327