Pseudomonas aeruginosa PAO1, PA3008 (sulA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3008
Name
sulA
Replicon chromosome
Genomic location 3368529 - 3369014 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251698.1
GI 15598204
Affymetrix PA3008_at
DNASU PaCD00007328
Entrez 880164
GenBank AAG06396.1
INSDC AAG06396.1
NCBI Locus Tag PA3008
protein_id(GenBank) gb|AAG06396.1|AE004726_2|gnl|PseudoCAP|PA3008
TIGR NTL03PA03008
UniParc UPI00000C58C4
UniProtKB Acc Q9HZJ8
UniProtKB ID SULA_PSEAE
UniRef100 UniRef100_Q9HZJ8
UniRef50 UniRef50_Q9HZJ8
UniRef90 UniRef90_Q9HZJ8

Product

Feature Type CDS
Coding Frame 1
Product Name
SulA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -1.11
Kyte-Doolittle Hydrophobicity Value -0.019
Molecular Weight (kDa) 17.5
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1OFU BACTERIAL CELL DIVISION INHIBITOR 04/21/03 Crystal structure of SulA:FtsZ from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA 2.1 X-RAY DIFFRACTION 100.0
1OFT BACTERIAL CELL DIVISION INHIBITOR 04/21/03 Crystal structure of SulA from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA 2.9 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 12 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002574 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3008
Search term: sulA
Search term: SulA

Human Homologs

References

Evolution of the enterobacterial sulA gene: a component of the SOS system encoding an inhibitor of cell division.
Freudl R, Braun G, Honoré N, Cole ST
Gene 1987;52(1):31-40
PubMed ID: 3297925
Crystal structure of the SOS cell division inhibitor SulA and in complex with FtsZ.
Cordell SC, Robinson EJ, Lowe J
Proc Natl Acad Sci U S A 2003 Jun 24;100(13):7889-94
PubMed ID: 12808143