Pseudomonas aeruginosa PAO1, PA3113 (trpF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3113
Name
trpF
Replicon chromosome
Genomic location 3493842 - 3494477 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251803.1
GI 15598309
Affymetrix PA3113_trpF_at
Entrez 877681
GenBank AAG06501.1
INSDC AAG06501.1
NCBI Locus Tag PA3113
protein_id(GenBank) gb|AAG06501.1|AE004735_8|gnl|PseudoCAP|PA3113
TIGR NTL03PA03113
UniParc UPI00001375FA
UniProtKB Acc Q59649
UniProtKB ID TRPF_PSEAE
UniRef100 UniRef100_Q59649
UniRef50 UniRef50_Q4KEZ9
UniRef90 UniRef90_Q59649

Product

Feature Type CDS
Coding Frame 1
Product Name
N-(5'phosphoribosyl)anthranilate (PRA) isomerase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -0.37
Kyte-Doolittle Hydrophobicity Value 0.056
Molecular Weight (kDa) 22.3
Isoelectric Point (pI) 6.78

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 517 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002485 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3113
Search term: trpF

Human Homologs

References

DNA sequences and characterization of four early genes of the tryptophan pathway in Pseudomonas aeruginosa.
Essar DW, Eberly L, Han CY, Crawford IP
J Bacteriol 1990 Feb;172(2):853-66
PubMed ID: 2105306
An evolutionary comparison of Acinetobacter calcoaceticus trpF with trpF genes of several organisms.
Ross CM, Kaplan JB, Winkler ME, Nichols BP
Mol Biol Evol 1990 Jan;7(1):74-81
PubMed ID: 2299982
The trpF nucleotide sequence and its promoter analysis in Pseudomonas aeruginosa.
Murata T
Microbiol Immunol 1996;40(2):107-14
PubMed ID: 8867605