Pseudomonas aeruginosa PAO1, PA3333 (fabH2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3333
Name
fabH2
Replicon chromosome
Genomic location 3742694 - 3743686 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252023.1
GI 15598529
Affymetrix PA3333_fabH2_at
Entrez 882498
GenBank AAG06721.1
INSDC AAG06721.1
NCBI Locus Tag PA3333
protein_id(GenBank) gb|AAG06721.1|AE004755_8|gnl|PseudoCAP|PA3333
TIGR NTL03PA03333
UniParc UPI00000C59BB
UniProtKB Acc Q9HYR2
UniProtKB ID FABH_PSEAE
UniRef100 UniRef100_B7V4R0
UniRef50 UniRef50_Q9JN82
UniRef90 UniRef90_B7V4R0

Product

Feature Type CDS
Coding Frame 1
Product Name
3-oxoacyl-[acyl-carrier-protein] synthase III
Product Name Confidence: Class 2
Synonyms acetyl CoA ACP transacetylase
beta-ketoacyl-ACP synthase III
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -8.44
Kyte-Doolittle Hydrophobicity Value 0.291
Molecular Weight (kDa) 34.0
Isoelectric Point (pI) 4.95

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2X3E TRANSFERASE 01/24/10 Crystal structure of 3-oxoacyl-(acyl carrier protein) synthase III, FabH from Pseudomonas aeruginosa PAO1 PSEUDOMONAS AERUGINOSA 1.81 X-RAY DIFFRACTION 99.7

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 591 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000962 (605 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3333
Search term: fabH2

Human Homologs

References

Isolation and characterization of the beta-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12.
Tsay JT, Oh W, Larson TJ, Jackowski S, Rock CO
J Biol Chem 1992 Apr 5;267(10):6807-14
PubMed ID: 1551888