Pseudomonas aeruginosa PAO1, PA3537 (argF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3537
Name
argF
Replicon chromosome
Genomic location 3959033 - 3959950 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252227.1
GI 15598733
Affymetrix PA3537_argF_at
DNASU PaCD00007556
Entrez 878793
GenBank AAG06925.1
INSDC AAG06925.1
NCBI Locus Tag PA3537
protein_id(GenBank) gb|AAG06925.1|AE004774_3|gnl|PseudoCAP|PA3537
TIGR NTL03PA03537
UniParc UPI0000165ED1
UniProtKB Acc P11724
UniProtKB ID OTC_PSEAE
UniRef100 UniRef100_P11724
UniRef50 UniRef50_Q02047
UniRef90 UniRef90_P11724

Product

Feature Type CDS
Coding Frame 1
Product Name
ornithine carbamoyltransferase, anabolic
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -8.22
Kyte-Doolittle Hydrophobicity Value -0.160
Molecular Weight (kDa) 33.9
Isoelectric Point (pI) 5.74

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 1
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 649 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002129 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3537
Search term: argF

Human Homologs

Ensembl 110, assembly GRCh38.p14
ornithine transcarbamylase [Source:HGNC Symbol;Acc:HGNC:8512]
E-value: 2.1e-61
Percent Identity: 40.8

References

Anabolic ornithine carbamoyltransferase of Pseudomonas aeruginosa: nucleotide sequence and transcriptional control of the argF structural gene.
Itoh Y, Soldati L, Stalon V, Falmagne P, Terawaki Y, Leisinger T, Haas D
J Bacteriol 1988 Jun;170(6):2725-34
PubMed ID: 3131308