Pseudomonas aeruginosa PAO1, PA3553 (arnC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3553
Name
arnC
Synonym: arnC
Synonym: pmrF
Replicon chromosome
Genomic location 3981005 - 3982024 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252243.1
GI 15598749
Affymetrix PA3553_at
DNASU PaCD00007559
Entrez 878472
GenBank AAG06941.1
INSDC AAG06941.1
NCBI Locus Tag PA3553
protein_id(GenBank) gb|AAG06941.1|AE004776_4|gnl|PseudoCAP|PA3553
TIGR NTL03PA03553
UniParc UPI00000C5A64
UniProtKB Acc Q9HY64
UniProtKB ID ARNC_PSEAE
UniRef100 UniRef100_B7VBN3
UniRef50 UniRef50_Q7N3Q6
UniRef90 UniRef90_B7VBN3

Product

Feature Type CDS
Coding Frame 1
Product Name
ArnC
Product Name Confidence: Class 2
Synonyms ArnC
Evidence for Translation
Detected using LC-MS/MS (37.30 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 3.05
Kyte-Doolittle Hydrophobicity Value 0.193
Molecular Weight (kDa) 37.3
Isoelectric Point (pI) 8.21

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Outer Membrane Vesicle Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 588 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002113 (840 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3553
Search term: arnC
Search term: ArnC

Human Homologs

Ensembl 110, assembly GRCh38.p14
ALG5 dolichyl-phosphate beta-glucosyltransferase [Source:HGNC Symbol;Acc:HGNC:20266]
E-value: 6.7e-08
Percent Identity: 34.0
Ensembl 110, assembly GRCh38.p14
ALG5 dolichyl-phosphate beta-glucosyltransferase [Source:HGNC Symbol;Acc:HGNC:20266]
E-value: 6.7e-08
Percent Identity: 34.0
Ensembl 110, assembly GRCh38.p14
ALG5 dolichyl-phosphate beta-glucosyltransferase [Source:HGNC Symbol;Acc:HGNC:20266]
E-value: 6.7e-08
Percent Identity: 34.0
Ensembl 110, assembly GRCh38.p14
ALG5 dolichyl-phosphate beta-glucosyltransferase [Source:HGNC Symbol;Acc:HGNC:20266]
E-value: 6.7e-08
Percent Identity: 34.0
Ensembl 110, assembly GRCh38.p14
ALG5 dolichyl-phosphate beta-glucosyltransferase [Source:HGNC Symbol;Acc:HGNC:20266]
E-value: 6.7e-08
Percent Identity: 34.0
Ensembl 110, assembly GRCh38.p14
ALG5 dolichyl-phosphate beta-glucosyltransferase [Source:HGNC Symbol;Acc:HGNC:20266]
E-value: 6.7e-08
Percent Identity: 34.0
Ensembl 110, assembly GRCh38.p14
ALG5 dolichyl-phosphate beta-glucosyltransferase [Source:HGNC Symbol;Acc:HGNC:20266]
E-value: 6.7e-08
Percent Identity: 34.0
Ensembl 110, assembly GRCh38.p14
ALG5 dolichyl-phosphate beta-glucosyltransferase [Source:HGNC Symbol;Acc:HGNC:20266]
E-value: 6.7e-08
Percent Identity: 34.0
Ensembl 110, assembly GRCh38.p14
ALG5 dolichyl-phosphate beta-glucosyltransferase [Source:HGNC Symbol;Acc:HGNC:20266]
E-value: 6.7e-08
Percent Identity: 34.0
Ensembl 110, assembly GRCh38.p14
ALG5 dolichyl-phosphate beta-glucosyltransferase [Source:HGNC Symbol;Acc:HGNC:20266]
E-value: 6.7e-08
Percent Identity: 34.0

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance.
Gunn JS, Lim KB, Krueger J, Kim K, Guo L, Hackett M, Miller SI
Mol Microbiol 1998 Mar;27(6):1171-82
PubMed ID: 9570402
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose.
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR
J Biol Chem 2005 Apr 8;280(14):14154-67
PubMed ID: 15695810
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344