Pseudomonas aeruginosa PAO1, PA3815 (iscR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3815
Name
iscR
Replicon chromosome
Genomic location 4272165 - 4272656 (- strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252504.1
GI 15599010
Affymetrix PA3815_at
DNASU PaCD00007662
Entrez 879919
GenBank AAG07202.1
INSDC AAG07202.1
NCBI Locus Tag PA3815
protein_id(GenBank) gb|AAG07202.1|AE004799_8|gnl|PseudoCAP|PA3815
TIGR NTL03PA03815
UniParc UPI00000C5B23
UniProtKB Acc Q9HXI7
UniProtKB ID Q9HXI7_PSEAE
UniRef100 UniRef100_W0YXJ3
UniRef50 UniRef50_Q6D258
UniRef90 UniRef90_M4XK35

Product

Feature Type CDS
Coding Frame 1
Product Name
IscR
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.48
Kyte-Doolittle Hydrophobicity Value -0.242
Molecular Weight (kDa) 17.9
Isoelectric Point (pI) 6.86

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 483 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001851 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3815
Search term: iscR
Search term: IscR

Human Homologs

References

IscR modulates catalase A (KatA) activity, peroxide resistance and full virulence of Pseudomonas aeruginosa PA14.
Kim SH, Lee BY, Lau GW, Cho YH
J Microbiol Biotechnol 2009 Dec;19(12):1520-6
PubMed ID: 20075613