Pseudomonas aeruginosa PAO1, PA3834 (valS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3834
Name
valS
Replicon chromosome
Genomic location 4291356 - 4294208 (+ strand)

Cross-References

RefSeq NP_252523.1
GI 15599029
Affymetrix PA3834_valS_at
Entrez 879905
GenBank AAG07221.1
INSDC AAG07221.1
NCBI Locus Tag PA3834
protein_id(GenBank) gb|AAG07221.1|AE004800_10|gnl|PseudoCAP|PA3834
TIGR NTL03PA03834
UniParc UPI00000C5B31
UniProtKB Acc Q9HXH0
UniProtKB ID SYV_PSEAE
UniRef100 UniRef100_Q9HXH0
UniRef50 UniRef50_Q9HXH0
UniRef90 UniRef90_Q9HXH0

Product

Feature Type CDS
Coding Frame 1
Product Name
valyl-tRNA synthetase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -24.53
Kyte-Doolittle Hydrophobicity Value -0.378
Molecular Weight (kDa) 107.7
Isoelectric Point (pI) 5.23

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4XKZ LIGASE 01/12/15 Crystal structure of the C-terminal anticodon loop binding domain of a valyl-tRNA synthetase from Pseudomonas aeruginosa Pseudomonas aeruginosa 1.95 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 668 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001832 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3834
Search term: valS

Human Homologs

Ensembl 110, assembly GRCh38.p14
valyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:12651]
E-value: 1.3e-210
Percent Identity: 42.2
Ensembl 110, assembly GRCh38.p14
valyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:12651]
E-value: 1.3e-210
Percent Identity: 42.2
Ensembl 110, assembly GRCh38.p14
valyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:12651]
E-value: 1.3e-210
Percent Identity: 42.2
Ensembl 110, assembly GRCh38.p14
valyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:12651]
E-value: 1.3e-210
Percent Identity: 42.2
Ensembl 110, assembly GRCh38.p14
valyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:12651]
E-value: 1.3e-210
Percent Identity: 42.2
Ensembl 110, assembly GRCh38.p14
valyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:12651]
E-value: 1.3e-210
Percent Identity: 42.2

References

Valyl-tRNA synthetase gene of Escherichia coli K12. Primary structure and homology within a family of aminoacyl-TRNA synthetases.
Heck JD, Hatfield GW
J Biol Chem 1988 Jan 15;263(2):868-77
PubMed ID: 3275660
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994