Pseudomonas aeruginosa PAO1, PA3857 (pcs)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3857
Name
pcs
Replicon chromosome
Genomic location 4316109 - 4316825 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252546.1
GI 15599052
Affymetrix PA3857_at
DNASU PaCD00007680
Entrez 879785
GenBank AAG07244.1
INSDC AAG07244.1
NCBI Locus Tag PA3857
protein_id(GenBank) gb|AAG07244.1|AE004802_13|gnl|PseudoCAP|PA3857
TIGR NTL03PA03857
UniParc UPI00000C5B45
UniProtKB Acc Q9HXE9
UniProtKB ID PCS_PSEAE
UniRef100 UniRef100_Q9HXE9
UniRef50 UniRef50_Q9HXE9
UniRef90 UniRef90_Q9HXE9

Product

Feature Type CDS
Coding Frame 1
Product Name
phosphatidylcholine synthase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 1.06
Kyte-Doolittle Hydrophobicity Value 0.878
Molecular Weight (kDa) 26.6
Isoelectric Point (pI) 7.50

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 51 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001812 (427 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3857
Search term: pcs

Human Homologs

References

Pseudomonas aeruginosa synthesizes phosphatidylcholine by use of the phosphatidylcholine synthase pathway.
Wilderman PJ, Vasil AI, Martin WE, Murphy RC, Vasil ML
J Bacteriol 2002 Sep;184(17):4792-9
PubMed ID: 12169604
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Cloning and characterization of the gene for phosphatidylcholine synthase.
Sohlenkamp C, de Rudder KE, Rohrs V, Lopez-Lara IM, Geiger O
J Biol Chem 2000 Jun 23;275(25):18919-25
PubMed ID: 10858449