Pseudomonas aeruginosa PAO1, PA3876 (narK2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3876
Name
narK2
Replicon chromosome
Genomic location 4342122 - 4343528 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252565.1
GI 15599071
Affymetrix PA3876_narK2_at
Entrez 879781
GenBank AAG07263.1
INSDC AAG07263.1
NCBI Locus Tag PA3876
protein_id(GenBank) gb|AAG07263.1|AE004805_1|gnl|PseudoCAP|PA3876
TIGR NTL03PA03876
UniParc UPI00000C5B53
UniProtKB Acc Q9HXD4
UniProtKB ID Q9HXD4_PSEAE
UniRef100 UniRef100_Q9HXD4
UniRef50 UniRef50_Q9HXD4
UniRef90 UniRef90_Q9HXD4

Product

Feature Type CDS
Coding Frame 1
Product Name
nitrite extrusion protein 2
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 10.31
Kyte-Doolittle Hydrophobicity Value 0.522
Molecular Weight (kDa) 50.6
Isoelectric Point (pI) 9.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database Victors : 4235
Category
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Notes
Infection model Rat agar bead model of chronic lung infection
Reference 14641575

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 206 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001795 (372 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3876
Search term: narK2

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
The narX and narL genes encoding the nitrate-sensing regulators of Escherichia coli are homologous to a family of prokaryotic two-component regulatory genes.
Nohno T, Noji S, Taniguchi S, Saito T
Nucleic Acids Res 1989 Apr 25;17(8):2947-57
PubMed ID: 2657652