Pseudomonas aeruginosa PAO1, PA3916 (moaE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3916
Name
moaE
Replicon chromosome
Genomic location 4385900 - 4386352 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252605.1
GI 15599111
Affymetrix PA3916_moaE_at
Entrez 878985
GenBank AAG07303.1
INSDC AAG07303.1
NCBI Locus Tag PA3916
protein_id(GenBank) gb|AAG07303.1|AE004809_3|gnl|PseudoCAP|PA3916
TIGR NTL03PA03916
UniParc UPI000012F338
UniProtKB Acc Q9HX97
UniProtKB ID MOAE_PSEAE
UniRef100 UniRef100_Q9HX97
UniRef50 UniRef50_Q9HX97
UniRef90 UniRef90_Q9HX97

Product

Feature Type CDS
Coding Frame 1
Product Name
molybdopterin converting factor, large subunit
Product Name Confidence: Class 2
Synonyms molybdopterin biosynthetic protein E
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.14
Kyte-Doolittle Hydrophobicity Value -0.283
Molecular Weight (kDa) 16.7
Isoelectric Point (pI) 6.11

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 424 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001760 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3916
Search term: moaE

Human Homologs

References

The biosynthesis of molybdopterin in Escherichia coli. Purification and characterization of the converting factor.
Pitterle DM, Rajagopalan KV
J Biol Chem 1993 Jun 25;268(18):13499-505
PubMed ID: 8514782
Molecular genetic analysis of the moa operon of Escherichia coli K-12 required for molybdenum cofactor biosynthesis.
Rivers SL, McNairn E, Blasco F, Giordano G, Boxer DH
Mol Microbiol 1993 Jun;8(6):1071-81
PubMed ID: 8361352