Pseudomonas aeruginosa PAO1, PA4047 (ribA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4047
Name
ribA
Replicon chromosome
Genomic location 4529995 - 4530612 (- strand)

Cross-References

RefSeq NP_252736.1
GI 15599242
Affymetrix PA4047_ribA_at
DNASU PaCD00007768
Entrez 879059
GenBank AAG07434.1
INSDC AAG07434.1
NCBI Locus Tag PA4047
protein_id(GenBank) gb|AAG07434.1|AE004821_7|gnl|PseudoCAP|PA4047
TIGR NTL03PA04047
UniParc UPI00000C5BDC
UniProtKB Acc Q9HWY1
UniProtKB ID RIBA_PSEAE
UniRef100 UniRef100_B7V7R1
UniRef50 UniRef50_Q32GQ6
UniRef90 UniRef90_A6V055

Product

Feature Type CDS
Coding Frame 1
Product Name
GTP cyclohydrolase II
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.44
Kyte-Doolittle Hydrophobicity Value -0.101
Molecular Weight (kDa) 22.1
Isoelectric Point (pI) 6.63

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 531 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001637 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4047
Search term: ribA

Human Homologs

References

Biosynthesis of riboflavin: cloning, sequencing, mapping, and expression of the gene coding for GTP cyclohydrolase II in Escherichia coli.
Richter G, Ritz H, Katzenmeier G, Volk R, Kohnle A, Lottspeich F, Allendorf D, Bacher A
J Bacteriol 1993 Jul;175(13):4045-51
PubMed ID: 8320220
The complete genome sequence of Escherichia coli K-12.
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y
Science 1997 Sep 5;277(5331):1453-62
PubMed ID: 9278503
Potential of Escherichia coli GTP cyclohydrolase II for hydrolyzing 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.
Kobayashi M, Ohara-Nemoto Y, Kaneko M, Hayakawa H, Sekiguchi M, Yamamoto K
J Biol Chem 1998 Oct 9;273(41):26394-9
PubMed ID: 9756871