Pseudomonas aeruginosa PAO1, PA4236 (katA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4236
Name
katA
Synonym: catA
Replicon chromosome
Genomic location 4752260 - 4753708 (- strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 7 transposon mutants in orthologs

Cross-References

RefSeq NP_252926.1
GI 15599432
Affymetrix PA4236_katA_at
Entrez 881831
GenBank AAG07624.1
INSDC AAG07624.1
NCBI Locus Tag PA4236
protein_id(GenBank) gb|AAG07624.1|AE004841_2|gnl|PseudoCAP|PA4236
TIGR NTL03PA04237
UniParc UPI0000127076
UniProtKB Acc O52762
UniProtKB ID CATA_PSEAE
UniRef100 UniRef100_O52762
UniRef50 UniRef50_P42321
UniRef90 UniRef90_O52762

Product

Feature Type CDS
Coding Frame 1
Product Name
catalase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected using LC-MS/MS (55.59 kDa, PMID:21751344)
Charge (pH 7) -3.20
Kyte-Doolittle Hydrophobicity Value -0.655
Molecular Weight (kDa) 55.6
Isoelectric Point (pI) 6.69

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Periplasmic Class 1
Outer Membrane Vesicle Class 1
Unknown (This protein may have multiple localization sites) Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4E37 OXIDOREDUCTASE 03/09/12 Crystal Structure of P. aeruginosa catalase, KatA tetramer Pseudomonas aeruginosa 2.53 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 315 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001474 (1465 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4236
Search term: katA
Search term: catalase

Human Homologs

Ensembl 110, assembly GRCh38.p14
catalase [Source:HGNC Symbol;Acc:HGNC:1516]
E-value: 2.9e-142
Percent Identity: 52.0

References

Cloning and characterization of the katB gene of Pseudomonas aeruginosa encoding a hydrogen peroxide-inducible catalase: purification of KatB, cellular localization, and demonstration that it is essential for optimal resistance to hydrogen peroxide.
Brown SM, Howell ML, Vasil ML, Anderson AJ, Hassett DJ
J Bacteriol 1995 Nov;177(22):6536-44
PubMed ID: 7592431
Crystal structure of Proteus mirabilis PR catalase with and without bound NADPH.
Gouet P, Jouve HM, Dideberg O
J Mol Biol 1995 Jun 23;249(5):933-54
PubMed ID: 7791219
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344