Pseudomonas aeruginosa PAO1, PA4276 (secE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4276
Name
secE
Synonym: prlG
Replicon chromosome
Genomic location 4783771 - 4784139 (- strand)

Cross-References

RefSeq NP_252966.1
GI 15599472
Affymetrix PA4276_secE_at
DNASU PaCD00007857
Entrez 881694
GenBank AAG07664.1
INSDC AAG07664.1
NCBI Locus Tag PA4276
protein_id(GenBank) gb|AAG07664.1|AE004843_6|gnl|PseudoCAP|PA4276
TIGR NTL03PA04277
UniParc UPI00000C5C90
UniProtKB Acc Q9HWC3
UniProtKB ID SECE_PSEAE
UniRef100 UniRef100_Q9HWC3
UniRef50 UniRef50_Q9HWC3
UniRef90 UniRef90_Q9HWC3

Product

Feature Type CDS
Coding Frame 1
Product Name
secretion protein SecE
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 3.98
Kyte-Doolittle Hydrophobicity Value 0.990
Molecular Weight (kDa) 13.4
Isoelectric Point (pI) 10.38

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 190 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001435 (442 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4276
Search term: secE

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
The secE gene encodes an integral membrane protein required for protein export in Escherichia coli.
Schatz PJ, Riggs PD, Jacq A, Fath MJ, Beckwith J
Genes Dev 1989 Jul;3(7):1035-44
PubMed ID: 2673920
The allele-specific synthetic lethality of prlA-prlG double mutants predicts interactive domains of SecY and SecE.
Flower AM, Osborne RS, Silhavy TJ
EMBO J 1995 Mar 1;14(5):884-93
PubMed ID: 7889938