Pseudomonas aeruginosa PAO1, PA4415 (mraY)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4415
Name
mraY
Synonym: ORF Y
Replicon chromosome
Genomic location 4948690 - 4949772 (- strand)

Cross-References

RefSeq NP_253105.1
GI 15599611
Affymetrix PA4415_mraY_at
DNASU PaCD00007913
Entrez 881288
GenBank AAG07803.1
INSDC AAG07803.1
NCBI Locus Tag PA4415
protein_id(GenBank) gb|AAG07803.1|AE004856_14|gnl|PseudoCAP|PA4415
TIGR NTL03PA04416
UniParc UPI000012F523
UniProtKB Acc Q9HVZ8
UniProtKB ID MRAY_PSEAE
UniRef100 UniRef100_A6VB88
UniRef50 UniRef50_A7ZHH8
UniRef90 UniRef90_Q87WY2

Product

Feature Type CDS
Coding Frame 1
Product Name
phospho-N-acetylmuramoyl-pentapeptide-transferase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 8.88
Kyte-Doolittle Hydrophobicity Value 0.823
Molecular Weight (kDa) 39.7
Isoelectric Point (pI) 9.85

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 600 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004005 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4415
Search term: mraY

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Phospho-N-acetylmuramoyl-pentapeptide-transferase of Escherichia coli K12. Properties of the membrane-bound and the extracted and partially purified enzyme.
Geis A, Plapp R
Biochim Biophys Acta 1978 Dec 8;527(2):414-24
PubMed ID: 215212
The Escherichia coli mraY gene encoding UDP-N-acetylmuramoyl-pentapeptide: undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide transferase.
Ikeda M, Wachi M, Jung HK, Ishino F, Matsuhashi M
J Bacteriol 1991 Feb;173(3):1021-6
PubMed ID: 1846850
The murG gene of Escherichia coli codes for the UDP-N-acetylglucosamine: N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase involved in the membrane steps of peptidoglycan synthesis.
Mengin-Lecreulx D, Texier L, Rousseau M, van Heijenoort J
J Bacteriol 1991 Aug;173(15):4625-36
PubMed ID: 1649817