Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA4425
|
Name |
Synonym: yraO |
Replicon | chromosome |
Genomic location | 4959926 - 4960519 (+ strand) |
Comment | Modeling evidence for S7P-isomerase. BLAST of PA4425 against NCBI showed E = 2e-59 with Sedoheptulose 7-phosphate isomerase Ralstonia eutropha H16. |
RefSeq | NP_253115.1 |
GI | 15599621 |
Affymetrix | PA4425_at |
Entrez | 881196 |
GenBank | AAG07813.1 |
INSDC | AAG07813.1 |
NCBI Locus Tag | PA4425 |
protein_id(GenBank) | gb|AAG07813.1|AE004857_4|gnl|PseudoCAP|PA4425 |
TIGR | NTL03PA04426 |
UniParc | UPI000012E842 |
UniProtKB Acc | Q9HVZ0 |
UniProtKB ID | GMHA_PSEAE |
UniRef100 | UniRef100_B7UZK3 |
UniRef50 | UniRef50_C1DQ86 |
UniRef90 | UniRef90_Q4ZNX7 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
sedoheptulose 7-phosphate isomerase GmhA
|
Synonyms | |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -7.89 |
Kyte-Doolittle Hydrophobicity Value | -0.023 |
Molecular Weight (kDa) | 21.4 |
Isoelectric Point (pI) | 4.72 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
3BJZ | ISOMERASE | 12/05/07 | Crystal structure of Pseudomonas aeruginosa phosphoheptose isomerase | Pseudomonas aeruginosa PAO1 | 2.4 | X-RAY DIFFRACTION | 100.0 |
1X92 | ISOMERASE | 08/19/04 | CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA PHOSPHOHEPTOSE ISOMERASE IN COMPLEX WITH REACTION PRODUCT D-GLYCERO-D-MANNOPYRANOSE-7-PHOSPHATE | Pseudomonas aeruginosa | 2.3 | X-RAY DIFFRACTION | 100.0 |
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
D-Glycero-D-Mannopyranose-7-Phosphate | DB02470 | DrugBank | 5.1.4 | Q9HVZ0 | Phosphoheptose isomerase | 100.0 | 197 | 8.7e-104 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 350 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG004015 (536 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA4425
Search term: sedoheptulose 7-phosphate isomerase GmhA
|
Involvement of the Haemophilus ducreyi gmhA gene product in lipooligosaccharide expression and virulence.
Bauer BA, Stevens MK, Hansen EJ
Infect Immun 1998 Sep;66(9):4290-8
PubMed ID: 9712780
|
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli.
Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P
J Bacteriol 2002 Jan;184(2):363-9
PubMed ID: 11751812
|