Pseudomonas aeruginosa PAO1, PA4449 (hisG)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4449
Name
hisG
Replicon chromosome
Genomic location 4983552 - 4984187 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_253139.1
GI 15599645
Affymetrix PA4449_hisG_at
DNASU PaCD00007926
Entrez 880968
GenBank AAG07837.1
INSDC AAG07837.1
NCBI Locus Tag PA4449
protein_id(GenBank) gb|AAG07837.1|AE004859_6|gnl|PseudoCAP|PA4449
TIGR NTL03PA04450
UniParc UPI000012C753
UniProtKB Acc Q9HVW8
UniProtKB ID HIS1_PSEAE
UniRef100 UniRef100_B7UZY8
UniRef50 UniRef50_Q87WV4
UniRef90 UniRef90_Q87WV4

Product

Feature Type CDS
Coding Frame 1
Product Name
ATP-phosphoribosyltransferase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 3.92
Kyte-Doolittle Hydrophobicity Value 0.012
Molecular Weight (kDa) 22.8
Isoelectric Point (pI) 9.34

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 565 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004038 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4449
Search term: hisG

Human Homologs

References

Structure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons.
Carlomagno MS, Chiariotti L, Alifano P, Nappo AG, Bruni CB
J Mol Biol 1988 Oct 5;203(3):585-606
PubMed ID: 3062174