Pseudomonas aeruginosa PAO1, PA4481 (mreB)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA4481
Name	mreB Synonym: rodY Synonym: envB
Replicon	chromosome
Genomic location	5012394 - 5013431 (- strand)

Cross-References

RefSeq	NP_253171.1
GI	15599677
Affymetrix	PA4481_mreB_at
Entrez	881165
GenBank	AAG07869.1
INSDC	AAG07869.1
NCBI Locus Tag	PA4481
protein_id(GenBank)	gb|AAG07869.1|AE004862_3|gnl|PseudoCAP|PA4481
TIGR	NTL03PA04482
UniParc	UPI00000C5D2E
UniProtKB Acc	Q9HVU0
UniProtKB ID	Q9HVU0_PSEAE
UniRef100	UniRef100_Q9HVU0
UniRef50	UniRef50_P44474
UniRef90	UniRef90_Q9HVU0

Product

Feature Type	CDS
Coding Frame	1
Product Name	rod shape-determining protein MreB Product Name Confidence: Class 2
Synonyms
Evidence for Translation	Detected using LC-MS/MS (36.98 kDa, PMID:21751344) Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7)	-6.38
Kyte-Doolittle Hydrophobicity Value	0.037
Molecular Weight (kDa)	37.0
Isoelectric Point (pI)	5.05

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543 Outer Membrane Vesicle Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 638 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG004070 (535 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA4481 Search term: mreB Search term: rod shape-determining protein MreB

Human Homologs

References

Determinations of the DNA sequence of the mreB gene and of the gene products of the mre region that function in formation of the rod shape of Escherichia coli cells. Doi M, Wachi M, Ishino F, Tomioka S, Ito M, Sakagami Y, Suzuki A, Matsuhashi M J Bacteriol 1988 Oct;170(10):4619-24 PubMed ID: 3049542

Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa. Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS Proteomics 2011 Aug;11(16):3424-9 PubMed ID: 21751344