Pseudomonas aeruginosa PAO1, PA4505 (dppD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4505
Name
dppD
Replicon chromosome
Genomic location 5044054 - 5045028 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253195.1
GI 15599701
Affymetrix PA4505_at
Entrez 881158
GenBank AAG07893.1
INSDC AAG07893.1
NCBI Locus Tag PA4505
protein_id(GenBank) gb|AAG07893.1|AE004864_5|gnl|PseudoCAP|PA4505
TIGR NTL03PA04506
UniParc UPI00000C5D41
UniProtKB Acc Q9HVR6
UniProtKB ID Q9HVR6_PSEAE
UniRef100 UniRef100_U9IKI5
UniRef50 UniRef50_Q4KIC6
UniRef90 UniRef90_A0A069PYH4

Product

Feature Type CDS
Coding Frame 1
Product Name
dipeptide ABC transporter ATP-binding protein DppD
Product Name Confidence: Class 1
Synonyms probable ATP-binding component of ABC transporter
Evidence for Translation
Detected using LC-MS/MS (35.43 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.01
Kyte-Doolittle Hydrophobicity Value 0.045
Molecular Weight (kDa) 35.4
Isoelectric Point (pI) 6.05

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Outer Membrane Vesicle Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004092 (509 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4505
Search term: dppD

Human Homologs

Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 10 [Source:HGNC Symbol;Acc:HGNC:41]
E-value: 9.2e-15
Percent Identity: 28.4

References

Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344
High-throughput screening of dipeptide utilization mediated by the ABC transporter DppBCDF and its substrate-binding proteins DppA1-A5 in Pseudomonas aeruginosa.
Pletzer D, Lafon C, Braun Y, Köhler T, Page MG, Mourez M, Weingart H
PLoS One 2014;9(10):e111311
PubMed ID: 25338022