Pseudomonas aeruginosa PAO1, PA4519 (speC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4519
Name
speC
Replicon chromosome
Genomic location 5060115 - 5061278 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253209.1
GI 15599715
Affymetrix PA4519_at
Entrez 881118
GenBank AAG07907.1
INSDC AAG07907.1
NCBI Locus Tag PA4519
protein_id(GenBank) gb|AAG07907.1|AE004866_1|gnl|PseudoCAP|PA4519
TIGR NTL03PA04520
UniParc UPI00000C5D4E
UniProtKB Acc Q9HVQ3
UniProtKB ID Q9HVQ3_PSEAE
UniRef100 UniRef100_W0Z6P4
UniRef50 UniRef50_Q4KID4
UniRef90 UniRef90_L8MFV0

Product

Feature Type CDS
Coding Frame 1
Product Name
ornithine decarboxylase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -11.60
Kyte-Doolittle Hydrophobicity Value -0.151
Molecular Weight (kDa) 43.6
Isoelectric Point (pI) 4.69

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 582 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004100 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4519
Search term: speC

Human Homologs

References

Identification of the putrescine biosynthetic genes in Pseudomonas aeruginosa and characterization of agmatine deiminase and N-carbamoylputrescine amidohydrolase of the arginine decarboxylase pathway.
Nakada Y, Itoh Y
Microbiology (Reading) 2003 Mar;149(Pt 3):707-714
PubMed ID: 12634339
The gene and the primary structure of ornithine decarboxylase from Saccharomyces cerevisiae.
Fonzi WA, Sypherd PS
J Biol Chem 1987 Jul 25;262(21):10127-33
PubMed ID: 3038869
Novel characteristics of Selenomonas ruminantium lysine decarboxylase capable of decarboxylating both L-lysine and L-ornithine.
Takatsuka Y, Onoda M, Sugiyama T, Muramoto K, Tomita T, Kamio Y
Biosci Biotechnol Biochem 1999 Jun;63(6):1063-9
PubMed ID: 10427692