Pseudomonas aeruginosa PAO1, PA4524 (nadC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4524
Name
nadC
Replicon chromosome
Genomic location 5068032 - 5068880 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253214.1
GI 15599720
Affymetrix PA4524_nadC_at
DNASU PaCD00007956
Entrez 878422
GenBank AAG07912.1
INSDC -
NCBI Locus Tag PA4524
protein_id(GenBank) gb|AAG07912.1|AE004866_6|gnl|PseudoCAP|PA4524
TIGR NTL03PA04525
UniParc UPI000012FC9B
UniProtKB Acc P30819
UniProtKB ID NADC_PSEAE
UniRef100 UniRef100_P30819
UniRef50 UniRef50_P30819
UniRef90 UniRef90_P30819

Product

Feature Type CDS
Coding Frame 1
Product Name
nicotinate-nucleotide pyrophosphorylase
Product Name Confidence: Class 2
Synonyms quinolinate phosphoribosyltransferase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -6.88
Kyte-Doolittle Hydrophobicity Value -0.098
Molecular Weight (kDa) 30.6
Isoelectric Point (pI) 5.07

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 558 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004104 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4524
Search term: nadC

Human Homologs

Ensembl 110, assembly GRCh38.p14
quinolinate phosphoribosyltransferase [Source:HGNC Symbol;Acc:HGNC:9755]
E-value: 7.0e-35
Percent Identity: 35.3
Ensembl 110, assembly GRCh38.p14
quinolinate phosphoribosyltransferase [Source:HGNC Symbol;Acc:HGNC:9755]
E-value: 7.0e-35
Percent Identity: 35.3

References

The Salmonella typhimurium nadC gene: sequence determination by use of Mud-P22 and purification of quinolinate phosphoribosyltransferase.
Hughes KT, Dessen A, Gray JP, Grubmeyer C
J Bacteriol 1993 Jan;175(2):479-86
PubMed ID: 8419294
A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase.
Eads JC, Ozturk D, Wexler TB, Grubmeyer C, Sacchettini JC
Structure 1997 Jan 15;5(1):47-58
PubMed ID: 9016724