Pseudomonas aeruginosa PAO1, PA4529 (coaE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4529
Name
coaE
Replicon chromosome
Genomic location 5073564 - 5074175 (+ strand)

Cross-References

RefSeq NP_253219.1
GI 15599725
Affymetrix PA4529_at
Entrez 878572
GenBank AAG07917.1
INSDC AAG07917.1
NCBI Locus Tag PA4529
protein_id(GenBank) gb|AAG07917.1|AE004867_3|gnl|PseudoCAP|PA4529
TIGR NTL03PA04530
UniParc UPI0000127CEA
UniProtKB Acc Q9HVP8
UniProtKB ID COAE_PSEAE
UniRef100 UniRef100_Q9HVP8
UniRef50 UniRef50_Q8FL55
UniRef90 UniRef90_Q9HVP8

Product

Feature Type CDS
Coding Frame 1
Product Name
dephosphocoenzyme A kinase
Product Name Confidence: Class 2
Synonyms CoaE protein
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.84
Kyte-Doolittle Hydrophobicity Value -0.241
Molecular Weight (kDa) 22.8
Isoelectric Point (pI) 6.81

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 572 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004110 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4529
Search term: coaE

Human Homologs

Ensembl 110, assembly GRCh38.p14
dephospho-CoA kinase domain containing [Source:HGNC Symbol;Acc:HGNC:26238]
E-value: 5.8e-23
Percent Identity: 37.3
Ensembl 110, assembly GRCh38.p14
dephospho-CoA kinase domain containing [Source:HGNC Symbol;Acc:HGNC:26238]
E-value: 5.8e-23
Percent Identity: 37.3
Ensembl 110, assembly GRCh38.p14
dephospho-CoA kinase domain containing [Source:HGNC Symbol;Acc:HGNC:26238]
E-value: 5.8e-23
Percent Identity: 37.3
Ensembl 110, assembly GRCh38.p14
dephospho-CoA kinase domain containing [Source:HGNC Symbol;Acc:HGNC:26238]
E-value: 5.8e-23
Percent Identity: 37.3
Ensembl 110, assembly GRCh38.p14
dephospho-CoA kinase domain containing [Source:HGNC Symbol;Acc:HGNC:26238]
E-value: 5.8e-23
Percent Identity: 37.3
Ensembl 110, assembly GRCh38.p14
dephospho-CoA kinase domain containing [Source:HGNC Symbol;Acc:HGNC:26238]
E-value: 5.8e-23
Percent Identity: 37.3
Ensembl 110, assembly GRCh38.p14
dephospho-CoA kinase domain containing [Source:HGNC Symbol;Acc:HGNC:26238]
E-value: 5.8e-23
Percent Identity: 37.3
Ensembl 110, assembly GRCh38.p14
dephospho-CoA kinase domain containing [Source:HGNC Symbol;Acc:HGNC:26238]
E-value: 5.8e-23
Percent Identity: 37.3
Ensembl 110, assembly GRCh38.p14
dephospho-CoA kinase domain containing [Source:HGNC Symbol;Acc:HGNC:26238]
E-value: 5.8e-23
Percent Identity: 37.3
Ensembl 110, assembly GRCh38.p14
dephospho-CoA kinase domain containing [Source:HGNC Symbol;Acc:HGNC:26238]
E-value: 5.8e-23
Percent Identity: 37.3
Ensembl 110, assembly GRCh38.p14
dephospho-CoA kinase domain containing [Source:HGNC Symbol;Acc:HGNC:26238]
E-value: 5.8e-23
Percent Identity: 37.3
Ensembl 110, assembly GRCh38.p14
dephospho-CoA kinase domain containing [Source:HGNC Symbol;Acc:HGNC:26238]
E-value: 5.8e-23
Percent Identity: 37.3

References

Identification of yacE (coaE) as the structural gene for dephosphocoenzyme A kinase in Escherichia coli K-12.
Mishra P, Park PK, Drueckhammer DG
J Bacteriol 2001 May;183(9):2774-8
PubMed ID: 11292795
Characterization of type IV pilus genes in plant growth-promoting Pseudomonas putida WCS358.
de Groot A, Heijnen I, de Cock H, Filloux A, Tommassen J
J Bacteriol 1994 Feb;176(3):642-50
PubMed ID: 7905475
Genetic characterization of a new type IV-A pilus gene cluster found in both classical and El Tor biotypes of Vibrio cholerae.
Fullner KJ, Mekalanos JJ
Infect Immun 1999 Mar;67(3):1393-404
PubMed ID: 10024587