Pseudomonas aeruginosa PAO1, PA4557 (lytB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4557
Name
lytB
Replicon chromosome
Genomic location 5104986 - 5105930 (- strand)

Cross-References

RefSeq NP_253247.1
GI 15599753
Affymetrix PA4557_lytB_at
DNASU PaCD00007972
Entrez 879669
GenBank AAG07945.1
INSDC AAG07945.1
NCBI Locus Tag PA4557
protein_id(GenBank) gb|AAG07945.1|AE004869_9|gnl|PseudoCAP|PA4557
TIGR NTL03PA04558
UniParc UPI000012D9B6
UniProtKB Acc Q9HVM7
UniProtKB ID ISPH_PSEAE
UniRef100 UniRef100_Q9HVM7
UniRef50 UniRef50_Q0BYQ0
UniRef90 UniRef90_Q9HVM7

Product

Feature Type CDS
Coding Frame 1
Product Name
LytB protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -9.21
Kyte-Doolittle Hydrophobicity Value -0.277
Molecular Weight (kDa) 34.8
Isoelectric Point (pI) 5.15

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 515 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004216 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4557
Search term: lytB
Search term: LytB protein

Human Homologs

References

Nucleotide sequence of the lsp-dapB interval in Escherichia coli.
Bouvier J, Stragier P
Nucleic Acids Res 1991 Jan 11;19(1):180
PubMed ID: 2011499
Identification of the Escherichia coli lytB gene, which is involved in penicillin tolerance and control of the stringent response.
Gustafson CE, Kaul S, Ishiguro EE
J Bacteriol 1993 Feb;175(4):1203-5
PubMed ID: 8432714
Occurrence of homologs of the Escherichia coli lytB gene in gram-negative bacterial species.
Potter S, Yang X, Boulanger MJ, Ishiguro EE
J Bacteriol 1998 Apr;180(7):1959-61
PubMed ID: 9537400