Pseudomonas aeruginosa PAO1, PA4587 (ccpR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4587
Name
ccpR
Replicon chromosome
Genomic location 5136317 - 5137357 (+ strand)
Transposon Mutants 6 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253277.1
GI 15599783
Affymetrix PA4587_ccpR_at
Entrez 881021
GenBank AAG07975.1
INSDC AAG07975.1
NCBI Locus Tag PA4587
protein_id(GenBank) gb|AAG07975.1|AE004872_6|gnl|PseudoCAP|PA4587
TIGR NTL03PA04588
UniParc UPI00001272FD
UniProtKB Acc P14532
UniProtKB ID CCPR_PSEAE
UniRef100 UniRef100_P14532
UniRef50 UniRef50_P14532
UniRef90 UniRef90_P14532

Product

Feature Type CDS
Coding Frame 1
Product Name
cytochrome c551 peroxidase precursor
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.20
Kyte-Doolittle Hydrophobicity Value -0.315
Molecular Weight (kDa) 37.4
Isoelectric Point (pI) 6.72

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 1
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1EB7 OXIDOREDUCTASE 07/24/01 Crystal structure of the di-haem cytochrome c peroxidase from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA 2.4 X-RAY DIFFRACTION 100.0
2VHD OXIDOREDUCTASE 11/20/07 Crystal Structure Of The Di-Haem Cytochrome C Peroxidase From Pseudomonas aeruginosa - Mixed Valence Form PSEUDOMONAS AERUGINOSA 2.3 X-RAY DIFFRACTION 100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Heme C DB03317 DrugBank 5.1.4 P14532 Cytochrome c551 peroxidase 100.0 346 1.1e-199

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 240 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004245 (412 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4587
Search term: ccpR

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Structural and functional features of Pseudomonas cytochrome c peroxidase.
Ellfolk N, Rönnberg M, Osterlund K
Biochim Biophys Acta 1991 Oct 11;1080(1):68-77
PubMed ID: 1657179
Crystal structure of the di-haem cytochrome c peroxidase from Pseudomonas aeruginosa.
Fülöp V, Ridout CJ, Greenwood C, Hajdu J
Structure 1995 Nov 15;3(11):1225-33
PubMed ID: 8591033