Pseudomonas aeruginosa PAO1, PA4602 (glyA3)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4602
Name
glyA3
Replicon chromosome
Genomic location 5160738 - 5161991 (+ strand)
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253292.1
GI 15599798
Affymetrix PA4602_glyA3_at
Entrez 881085
GenBank AAG07990.1
INSDC AAG07990.1
NCBI Locus Tag PA4602
protein_id(GenBank) gb|AAG07990.1|AE004874_3|gnl|PseudoCAP|PA4602
TIGR NTL03PA04603
UniParc UPI000012B4EC
UniProtKB Acc Q9HVI7
UniProtKB ID GLYA3_PSEAE
UniRef100 UniRef100_Q9HVI7
UniRef50 UniRef50_D3DKC4
UniRef90 UniRef90_Q4K5R9

Product

Feature Type CDS
Coding Frame 1
Product Name
serine hydroxymethyltransferase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -6.50
Kyte-Doolittle Hydrophobicity Value -0.087
Molecular Weight (kDa) 45.2
Isoelectric Point (pI) 5.97

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 654 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003094 (1150 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4602
Search term: glyA3

Human Homologs

Ensembl 110, assembly GRCh38.p14
serine hydroxymethyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:10852]
E-value: 4.1e-92
Percent Identity: 45.9
Ensembl 110, assembly GRCh38.p14
serine hydroxymethyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:10852]
E-value: 4.1e-92
Percent Identity: 45.9
Ensembl 110, assembly GRCh38.p14
serine hydroxymethyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:10852]
E-value: 4.1e-92
Percent Identity: 45.9
Ensembl 110, assembly GRCh38.p14
serine hydroxymethyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:10852]
E-value: 4.1e-92
Percent Identity: 45.9

References

Cloning and characterization of the gene for Salmonella typhimurium serine hydroxymethyltransferase.
Urbanowski ML, Plamann MD, Stauffer LT, Stauffer GV
Gene 1984 Jan;27(1):47-54
PubMed ID: 6325301
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994