Pseudomonas aeruginosa PAO1, PA4635

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4635
Name
Synonym: mgtC
Replicon chromosome
Genomic location 5203668 - 5204372 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253325.1
GI 15599831
Affymetrix PA4635_at
DNASU PaCD00008008
Entrez 881216
GenBank AAG08023.1
INSDC AAG08023.1
NCBI Locus Tag PA4635
protein_id(GenBank) gb|AAG08023.1|AE004878_1|gnl|PseudoCAP|PA4635
TIGR NTL03PA04636
UniParc UPI00000C5D9F
UniProtKB Acc Q9HVF6
UniProtKB ID Q9HVF6_PSEAE
UniRef100 UniRef100_W0YY64
UniRef50 UniRef50_B4EYQ9
UniRef90 UniRef90_A6VC28

Product

Feature Type CDS
Coding Frame 1
Product Name
conserved hypothetical protein
Product Name Confidence: Class 4
Synonyms
Evidence for Translation
Charge (pH 7) -1.67
Kyte-Doolittle Hydrophobicity Value 0.383
Molecular Weight (kDa) 25.2
Isoelectric Point (pI) 5.84

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7QA5 UNKNOWN FUNCTION 11/16/21 Solution structure of the C terminal domain of MgtC (PA4635) from Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) NOT SOLUTION NMR 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 319 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004286 (426 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4635

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
The mgtB Mg2+ transport locus of Salmonella typhimurium encodes a P-type ATPase.
Snavely MD, Miller CG, Maguire ME
J Biol Chem 1991 Jan 15;266(2):815-23
PubMed ID: 1824701