Pseudomonas aeruginosa PAO1, PA4655 (hemH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4655
Name
hemH
Synonym: visA
Replicon chromosome
Genomic location 5222540 - 5223562 (- strand)

Cross-References

RefSeq NP_253344.1
GI 15599850
Affymetrix PA4655_hemH_at
DNASU PaCD00008020
Entrez 881311
GenBank AAG08042.1
INSDC AAG08042.1
NCBI Locus Tag PA4655
protein_id(GenBank) gb|AAG08042.1|AE004879_8|gnl|PseudoCAP|PA4655
TIGR NTL03PA04656
UniParc UPI000012C5E4
UniProtKB Acc Q9HVD7
UniProtKB ID HEMH_PSEAE
UniRef100 UniRef100_B7V0K1
UniRef50 UniRef50_Q4K6B3
UniRef90 UniRef90_B7V0K1

Product

Feature Type CDS
Coding Frame 1
Product Name
ferrochelatase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.74
Kyte-Doolittle Hydrophobicity Value -0.157
Molecular Weight (kDa) 38.6
Isoelectric Point (pI) 6.85

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 390 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004305 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4655
Search term: hemH
Search term: ferrochelatase

Human Homologs

References

The Escherichia coli visA gene encodes ferrochelatase, the final enzyme of the heme biosynthetic pathway.
Frustaci JM, O'Brian MR
J Bacteriol 1993 Apr;175(7):2154-6
PubMed ID: 8458858
Overproduction, purification, and characterization of ferrochelatase from Escherichia coli.
Miyamoto K, Kanaya S, Morikawa K, Inokuchi H
J Biochem 1994 Mar;115(3):545-51
PubMed ID: 8056770