Pseudomonas aeruginosa PAO1, PA4662 (murI)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4662
Name
murI
Replicon chromosome
Genomic location 5230114 - 5230911 (- strand)

Cross-References

RefSeq NP_253351.1
GI 15599857
Affymetrix PA4662_murI_at
DNASU PaCD00008024
Entrez 881345
GenBank AAG08049.1
INSDC AAG08049.1
NCBI Locus Tag PA4662
protein_id(GenBank) gb|AAG08049.1|AE004880_5|gnl|PseudoCAP|PA4662
TIGR NTL03PA04663
UniParc UPI000012FA13
UniProtKB Acc Q9HVD0
UniProtKB ID MURI_PSEAE
UniRef100 UniRef100_B7V0K8
UniRef50 UniRef50_Q888B8
UniRef90 UniRef90_B7V0K8

Product

Feature Type CDS
Coding Frame 1
Product Name
glutamate racemase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.67
Kyte-Doolittle Hydrophobicity Value 0.237
Molecular Weight (kDa) 28.3
Isoelectric Point (pI) 5.18

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 508 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004312 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4662
Search term: murI

Human Homologs

References

Identification of the Escherichia coli murI gene, which is required for the biosynthesis of D-glutamic acid, a specific component of bacterial peptidoglycan.
Doublet P, van Heijenoort J, Mengin-Lecreulx D
J Bacteriol 1992 Sep;174(18):5772-9
PubMed ID: 1355768
The murI gene of Escherichia coli is an essential gene that encodes a glutamate racemase activity.
Doublet P, van Heijenoort J, Bohin JP, Mengin-Lecreulx D
J Bacteriol 1993 May;175(10):2970-9
PubMed ID: 8098327